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Assessoria em Comunicação Pública
Aliciador
Jan 26, 2010 15:55
14 yrs ago
2 viewers *
Portuguese term

Leucemia Linfóide Aguda Pediátrica

Portuguese to English Medical Medical (general)
Leucemia Linfóide Aguda Pediátrica
Proposed translations (English)
5 +4 pediatric acute lymphoblastic leukemia
4 +2 Acute paediatric lymphoid/lymphocytic leukemia
5 +1 pediatric acute lymphocytic leukemia

Discussion

Muriel Vasconcellos Jan 27, 2010:
"leucemia linfoblastica aguda" also exists The term with "linfoblastica" also exists in Spanish (81,200 hits for ["leucemia linfoblastica']). The author had the option of using it and chose not to. That's another reason why I prefer 'lymphocytic'.
Muriel Vasconcellos Jan 27, 2010:
Criteria In the work I do, ICD trumps NCI. The terms in the ICD are agreed on after consultation with all the countries. The USPHS version of the ICD, for example, differs slightly and we were instructed not to use it in translations for the World Health Organization. Obviously there is some hair-splitting going on here and the difference can't be that important. This is a good example of the importance of deciding on and sticking to the references to be followed.
Filippe Vasconcellos de Freitas Guimarães Jan 27, 2010:
From the NCI Dictionary of Cancer Terms acute lymphoblastic leukemia
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphocytic leukemia and ALL.

http://www.cancer.gov/dictionary/?CdrID=45586
Filippe Vasconcellos de Freitas Guimarães Jan 27, 2010:
Actually, they are Acute lymphocytic leukemia != acute exacerbation of CLL.
Chronic leukemias can have phases in which the disease "behaves" as an acute leukemia (in the myeloid leukemias, this is known as a "blast crisis"). The underlying entity is still entirely different from acute leukemia.
See e.g. this old study: http://content.karger.com/ProdukteDB/produkte.asp?Doi=207150
Muriel Vasconcellos Jan 27, 2010:
Not synonymous after all? I have pasted in a section from the latest International Classification of Diseases, published by the World Health Organization (ICD-10) in my answer below (so that the columns will show). It appears that the two diseases may not be not synonymous after all. Notice C91.0 and C91.1, where "acute lymphoblastic leukemia excludes acute exacerbation of chronic lymphocytic leukemia."

According to this classification, 'acute lymphocytic leukemia' would really be: 'acute exacerbation of chronic lymphocytic leukemia'

Proposed translations

+4
2 mins
Selected

pediatric acute lymphoblastic leukemia

http://emedicine.medscape.com/article/990113-overview
http://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

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Note added at 3 mins (2010-01-26 15:58:27 GMT)
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Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing nearly one third of all pediatric cancers. The annual incidence rate for acute lymphoblastic leukemia is 30.9 cases per million population. The peak incidence occurs in children aged 2-5 years.
http://emedicine.medscape.com/article/990113-overview

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Note added at 3 mins (2010-01-26 15:58:54 GMT)
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Leucemia linfóide aguda (ou LLA), também conhecida como leucemia linfoblástica aguda, é um câncer das células brancas (leucócitos) do sangue caracterizada pela produção maligna de linfócitos imaturos (linfoblastos) na medula óssea.
http://pt.wikipedia.org/wiki/Leucemia_linfoide_aguda

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Note added at 5 hrs (2010-01-26 21:45:30 GMT)
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http://www.cancer.gov/cancertopics/pdq/treatment/childALL/Pa...
Peer comment(s):
agree Zoe Perry
8 mins
Thank you, Zoe!
agree Marlene Curtis
32 mins
Obrigado, Marlene!
agree Ana Resende
2 hrs
Obrigado, Ana!
neutral Muriel Vasconcellos : My latest discovery - checking with ICD-10 (duh!) - trumps my previous comments. I don't think they're synonymous after all.
5 hrs
Hi Muriel! True, but "lymphoblastic" is used (and recommended) by the National Cancer Institute, which is my usual source. I get +2m hits for "lymphoblastic" and -800k for "lymphocytic".
agree Paula Vaz-Carreiro
18 hrs
Thank you, Paula!
Something went wrong...
4 KudoZ points awarded for this answer.
+2
19 mins

Acute paediatric lymphoid/lymphocytic leukemia

Lymphoid & lymphocytic are the same thing.
Peer comment(s):
agree Cristinan
12 mins
Tks Cristinan
agree Scott Salvo : this is correct acute is the adverb describing the adjective pediatric the type of lymphoid leukemia so it should be before pediatric
29 mins
Tks, Scott
neutral Muriel Vasconcellos : After much research, I've come up with a different answer based on the International Classification of Diseases, 10th rev.
4 hrs
Well done, Muriel!
Something went wrong...
+1
5 hrs

pediatric acute lymphocytic leukemia

38,300 refs - vs. 26,200 for "lymphoblastic".

I found references for "lymphocytic" from the World Health Organization and the US Federal Drug Administration:

with high dose methotrexate for pediatric acute lymphocytic leukemia and lymphoma with examination of renal functions such as GFR before treatment and after ...
www.who.int/entity/selection_medicines/.../2/Methotrexate_r...

Apr 30, 2009 ... Pediatric Acute Lymphocytic Leukemia. Adult Acute Lymphocytic Leukemia. Pediatric Acute Myeloid Leukemia. Adult Acute Myeloid Leukemia ...
www.fda.gov/AboutFDA/CentersOffices/CDER/ucm120860.htm

"Acute Lymphoblastic Leukemia in Children, Pediatric Acute Lymphocytic Leukemia, ALL in Children, Juvenile Acute Lymphocytic Leukemia, Pediatric ALL, ...
www.healthline.com/search?q1=acute myelomonocytic.

Other reliable sources:

DISEASE CHARACTERISTICS: Histologically confirmed malignancy including: - Pediatric acute lymphocytic leukemia (ALL) in first complete remission with high ...
clinicaltrials.gov/ct2/show/NCT00003661 - Cached - Similar -

... Metastatic Bone Tumors; Neuroblastoma; Non-Hodgkin's Lymphoma; Pediatric Acute Lymphocytic Leukemia (ALL); Pediatric Brain Cancer; Pediatric Cancer ...
my.clevelandclinic.org/staff_directory/staff_display.aspx?...8945

Small's proposal is “Translating FLT3 inhibition into improved therapy for pediatric acute myeloid leukemia and pediatric acute lymphocytic leukemia.” ...
www.hopkinskimmelcancercenter.org/index.cfm?cID=1692

Methylation, aging, and pediatric acute lymphocytic leukemia. G Garcia-Manero1. 1Department of Leukemia, University of Texas, MD Anderson Cancer Center, ...
www.nature.com › Journal home › Archive › Commentary

... have been reported after previous exposure to alkylating chemotherapeutic agents, most commonly after treatment of pediatric acute lymphocytic leukemia. ...
www.cancernetwork.com/cancer-management.../1406417

DailyMed: About DailyMed
Representative Dose Schedule and Combination for the Approved Indication of Remission Induction in Pediatric Acute Lymphocytic Leukemia ...
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14760

For example, in pediatric acute lymphocytic leukemia (ALL), those which are hyperdiploid (have more than 46 chromosomes) or the t(12;21) have a favorable ...
www.wipo.int/pctdb/ja/ia.jsp?ia=US2007/076104&IA... - Cached -

Population Pharmacokinetic Studies in Pediatrics: Issues in Design ...
by B Meibohm - Related articles
One example of a drug where a limited sampling model was shown to be relevant is etoposide, used in the treatment of pediatric acute lymphocytic leukemia, ...
www.aapsj.org/view.asp?art=aapsj070248 - Cached - Similar -

Fludara Official FDA information, side effects and uses.
The Fludarabine regimen tested for pediatric acute lymphocytic leukemia (ALL) patients was a loading bolus of 10.5 mg/m2/day followed by a continuous ...
www.drugs.com/pro/fludara.html

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Note added at 8 hrs (2010-01-27 00:52:01 GMT)
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I am now no longer certain that the two terms are synonymous. Below is an extract from the International Classification of Diseases, 10th rev.

C91 Lymphoid leukaemia
Includes: morphology codes M982, M9940-M9941 with behaviour code /3
C91.0 Acute lymphoblastic leukaemia
Excludes: acute exacerbation of chronic lymphocytic leukaemia ( C91.1 )
C91.1 Chronic lymphocytic leukaemia
C91.2 Subacute lymphocytic leukaemia
C91.3 Prolymphocytic leukaemia
C91.4 Hairy-cell leukaemia
Leukaemic reticuloendotheliosis
C91.5 Adult T-cell leukaemia
C91.7 Other lymphoid leukaemia
C91.9 Lymphoid leukaemia, unspecified
Peer comment(s):
agree Filippe Vasconcellos de Freitas Guimarães : sure, synonymous and widely used //Yeah, so was mine! :) "a. lymphoblastic leukemia" vs. "a. lymphocytic leukemia", in quotes... I did leave out "pediatric", though. //Yep. And you were right the first time around: they are certainly synonyms.
11 mins
Thanks, Filippe! My search was for the whole string, not just the words "lymphocytic" vs. "lymphoblastic". Hmm... And you used Google?
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