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English to Spanish: Aronova 1972 General field: Science Detailed field: Medical: Pharmaceuticals
Source text - English The 4-substituted derivatives (III) (R1=alkyl) are obtained in high yields by the direct C-acylation of the azlactones (II) (R1=alkyl) in pyridine [1,2] or the O - C-isomerization under the influence of the same base of the O-azylazlactones (IV) (R1=Alkyl), which are formed from (II) and ClCOR2 in the presence of triethylamine in tetrahydrofuran. The C-acylation of the 4-substituted derivatives (II) (R1=H) in either pyridine or β-picoline proceeds much more poorly. For example, When 2-phenyl-5-oxazolinone (IIa) (R=C5H5, R1=H) is reacted with ClCO(CH2)2COOCH3 (V) in β-picoline the corresponding C-acyl derivative (IIIa) (R=C5H5), R1=H, R2=(CH2)COOCH3) is isolated in a total yield of only 10%. Data on the conditions for the O-C isomerization of (IV) (R1=H) are absent in literature.
Translation - Spanish Los derivados (III) sustituidos en posición 4 (R1=alquilo) se obtienen con altos rendimientos por C-acilación directa azlactonas (II) (R1=alquilo) en piridina [1, 2], o por la isomerización O—C bajo la influencia de la misma base de O-acilazlactonas (IV) (R1=alquilo), las cuales se forman de (II) y ClCOR2 en presencia de trietilamina en tetrahidrofurano. La C-acilación de los derivados (II) sustituidos en posición 4 (R1-H) en piridina o en β-picolina es mucho más pobre. Por ejemplo, cuando la 2-fenil-5-oxazolinona (IIa) (R = C5H5, R1= H) se hace reaccionar con ClCO(CH2)2COOCH3 (V) en β-picolina el C-acil derivado correspondiente (IIIa) (R = C6H5, R1= H, R2 = (CH2)2COOCH3) se aísla en un rendimiento total de sólo 10%. Los datos en las condiciones para la isomerización de O-C de (IV) (R1= H) están ausentes en la literatura.
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Bachelor's degree - Faculty of Chemistry, National Autonomous University of Mexico
Experience
Years of experience: 10. Registered at ProZ.com: Mar 2017.
Spanish to English (International English Language Testing System) Portuguese to Spanish (Centro de Enseñanza de Lenguas Extranjeras (UNAM)) English to Spanish (International English Language Testing System)
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Adobe Acrobat, Adobe Photoshop, Google Translator Toolkit, MateCat, Microsoft Excel, Microsoft Office Pro, Microsoft Word, Powerpoint
Bio
I have a degree in Chemical Engineering and a Master Degree in Fire Safety Engineering, and I am certified in Advanced Academic English. I've been a pharmaceutical translator for 7 years, working with clinical trials, scientific papers, analytical procedures and validations, batch analysis, stability studies, certificates of analysis, toxicity reports, drug safety, user manuals, safety data sheets (MSDS). Furthermore, I have experience in the fields of engineering, safety and electromechanics.
Keywords: English, Portuguese, Spanish, pharmaceuticals, materials, engineering, medical devices, clinical studies, confidential, attention to detail.
